Effect of chemoprevention by low-dose aspirin of new or recurrent colorectal adenomas in patients with Lynch syndrome (AAS-Lynch): study protocol for a multicenter, double-blind, placebo-controlled randomized controlled trial
AbstractLynch syndrome (LS) is the most common cause of inherited colorectal cancer (CRC) and confers a high lifetime risk of CRC estimated to be up to 60%. Colonoscopy is recommended every 2 years in LS patients above the 20–25-year-old age bracket, and every year when colonic neoplasia has been detected. Efficient chemoprevention has the potential to represent a cost-effective intervention in these high-risk patients and could allow a delay in colonoscopy surveillance. Several epi demiological studies have shown that regular use of low dose aspirin is associated with a 20 to 30% reduction in the risk of sporadic col...
Source: Trials - September 3, 2020 Category: Research Source Type: clinical trials
Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation
Conditions: Cancer Gene Mutation; Lynch Syndrome; Endometrial Cancer; Somatic Mutation Intervention: Diagnostic Test: Mismatch repair instability somatic and germline testing Sponsor: RWJ Barnabas Health at Jersey City Medical Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 17, 2020 Category: Research Source Type: clinical trials
Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome
Conditions: Hereditary Breast and Ovarian Cancer; Lynch Syndrome Intervention: Other: Families Accelerating Cascade Testing Toolkit Sponsors: Washington University School of Medicine; Barnes-Jewish Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 11, 2020 Category: Research Source Type: clinical trials
