The gametocytocidal efficacy of primaquine in malaria asymptomatic carriers treated with dihydroartemisinin-piperaquine in The Gambia (PRINOGAM): study protocol for a randomised controlled trial
Discussion
Sub-Saharan Africa, with a relatively high but poorly characterized G6PD prevalence, could potentially benefit from the use of primaquine to further reduce or interrupt malaria transmission. However, G6PD screening may not be feasible given the cost and difficulties in interpreting test results in terms of risk of haemolysis. Because the haemolytic effect of primaquine is dose-dependent, determining the minimal gametocytocidal and transmission-blocking dose of primaquine is extremely important to help address public health concerns over its safety and validate the efficacy of lower than rec...
Source: Trials - March 1, 2015 Category: Research Source Type: clinical trials
A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh
Condition: MalariaInterventions: Drug: chloroquine; Drug: Artemether-lumefantrine combination; Drug: Primaquine; Drug: PrimaquineSponsors: Menzies School of Health Research; International Centre for Diarrhoeal Disease Research, BangladeshActive, not recruiting - verified March 2015 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 5, 2015 Category: Research Source Type: clinical trials
Safety of Primaquine + Artemether-lumefantrine in G6PD Deficient Males With an Asymptomatic Malaria Infection (SAFEPRIM)
Condition: MalariaInterventions: Drug: Artemether-Lumefantrine (AL) + 0.25 mg/kg primaquine; Drug: Artemether-Lumefantrine (AL) combination; Drug: Artemether-Lumefantrine (AL) + 0.4 mg/kg primaquineSponsors: London School of Hygiene and Tropical Medicine; Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso; University Medical Center NijmegenRecruiting - verified October 2014 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 25, 2014 Category: Research Source Type: clinical trials
