A double-blind placebo-controlled trial of azithromycin to reduce mortality and improve growth in high-risk young children with non-bloody diarrhoea in low resource settings: the Antibiotics for Children with Diarrhoea (ABCD) trial protocol
DiscussionExpanding the treatment of acute watery diarrhoea in high-risk children to include an antibiotic may offer an opportunity to reduce deaths. These benefits may result from direct antimicrobial effects on pathogens or other incompletely understood mechanisms including improved nutrition, alterations in immune responsiveness or improved enteric function. The expansion of indications for antibiotic use raises concerns about the emergence of antimicrobial resistance both within treated children and the communities in which they live. ABCD will monitor antimicrobial resistance. The ABCD trial has important policy impli...
Source: Trials - January 12, 2020 Category: Research Source Type: clinical trials
Shigella CVD 30000: Study of Responses to Vaccination With Shigella Vaccine
Condition: Shigella Interventions: Biological: SF2a-TT15 Shigella Vaccine; Other: Placebo; Biological: S. flexneri 2a strain 2457T Challenge Agent Sponsor: University of Maryland, Baltimore Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 4, 2019 Category: Research Source Type: clinical trials
