Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists of the nociceptin/orphanin FQ opioid peptide (NOP) receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those of other members of the opioid receptor family. Therefore, we investigated whether different NOP receptor ligands showed differential signaling or functional selectivity at the NOP receptor. Using newly developed phosphosite-specific antibodies to the NOP receptor, we found that agonist-induced NOP receptor phosphorylation occurred primarily at four carboxyl-terminal serine (Ser) and threonine (Th...
Source: Signal Transduction Knowledge Environment - March 26, 2019 Category: Science Authors: Mann, A., Mouledous, L., Froment, C., ONeill, P. R., Dasgupta, P., Günther, T., Brunori, G., Kieffer, B. L., Toll, L., Bruchas, M. R., Zaveri, N. T., Schulz, S. Tags: STKE Research Articles Source Type: news

Celgene Submits Application to FDA for Ozanimod for the Treatment of Relapsing Forms of Multiple Sclerosis
SUMMIT, N.J.--(BUSINESS WIRE)--March 25, 2019 Celgene Corporation (NASDAQ:CELG) today announced that the Company has submitted a New Drug Application to the U.S. Food and Drug Administration (FDA) for ozanimod for the treatment of adults with... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 25, 2019 Category: Drugs & Pharmacology Source Type: news

Donor Features, Procedures and Outcomes in Fecal Transplant Donor Features, Procedures and Outcomes in Fecal Transplant
This comprehensive review examined donor characteristics and screening protocols for fecal microbiota transplantation, as well as FMT procedures and outcomes.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 25, 2019 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Drug Addiction Stigma Is Like Old Cancer Stigma Drug Addiction Stigma Is Like Old Cancer Stigma
Physicians who judge patients who have substance use disorders might want to reflect on the past stigmatization of cancer, says a cancer specialist.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 25, 2019 Category: Drugs & Pharmacology Tags: Hematology-Oncology News Source Type: news

azathioprine (Azasan)
Title: azathioprine (Azasan)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 3/25/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - March 25, 2019 Category: Drugs & Pharmacology Source Type: news

Nikki (Drospirenone and Ethinyl Estradiol Tablets) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 25, 2019 Category: Drugs & Pharmacology Source Type: news

Gonal-f RFF (Follitropin Alfa Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 25, 2019 Category: Drugs & Pharmacology Source Type: news

FDA Issues Complete Response Letter for Zynquista (sotagliflozin)
PARIS and THE WOODLANDS, TX–  March 22, 2019 -  The U.S. Food and Drug Administration (FDA) issued a Complete Response Letter (CRL) regarding the New Drug Application for investigational Zynquista (sotagliflozin)*, a dual SGLT1 and... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - March 25, 2019 Category: Drugs & Pharmacology Source Type: news

How Long Does Fecal Shedding Occur for Oral Vaccines?
Discussion Vaccination has reduced infectious disease morbidity and mortality since its introduction. Vaccines can be given intramuscularly, subcutaneously or orally. Oral virus vaccines currently used in the US include rotavirus, cholera, typhoid and adenovirus. Adenovirus vaccine is used in military personnel. As these are attenuated viruses there is concern for household contacts who are immunocompromised who may inadvertently be exposed to the virus through fecal shedding. Additionally, there is a concern that the attenuated virus may mutate and revert back to its wild-form and potentially cause disease. Injectable po...
Source: PediatricEducation.org - March 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Building up the pharmacy workforce
Commenting on'Closing the Gap', the report on the needs of the NHS workforce in Englandfrom the Nuffield Trust, The King's Fund and the Health Foundation, Sandra Gidley, Chair of the RPS (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Class 2 Medicines recall: Accord Healthcare Limited — Losartan potassium 50mg and 100mg film-coated tablets
Accord Healthcare Limited is recalling some batches of losartan potassium 50mg and 100mg film-coated tablets. (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

MHRA Drug Safety Update - Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects
The MHRA has released a Drug Safety Update regarding new restrictions and precautions for fluoroquinolone antibiotics... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Gianvi (Drospirenone/Ethinyl Estradiol) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Rocklatan (Netarsudil and Latanoprost Ophthalmic Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Folic Acid (Folic Acid) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Lotemax SM (Loteprednol Etabonate Ophthalmic Gel) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Statex (Morphine Sulfate Drops, Suppositories, Syrup, Tablets) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

() - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Caelyx (Pegylated Liposomal Doxorubicin Hydrochloride Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 22, 2019 Category: Drugs & Pharmacology Source Type: news

Acyclovir Capsules, USP (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Acyclovir Tablets, USP (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Haloperidol Tablets (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Statins Tied to Insulin Resistance, Higher Serum Fasting Insulin
THURSDAY, March 21, 2019 -- Individuals using statins may be at higher risk for hyperglycemia, insulin resistance, and eventually type 2 diabetes, according to a study published online March 5 in the British Journal of Clinical Pharmacology. Fariba... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 21, 2019 Category: Pharmaceuticals Source Type: news

albuterol and ipratropium inhaler (Combivent Respimat)
Title: albuterol and ipratropium inhaler (Combivent Respimat)Category: MedicationsCreated: 4/4/1999 12:00:00 AMLast Editorial Review: 3/21/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Loryna (Drospirenone and Ethinyl Estradiol Tablets) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Esomeprazole Magnesium Capsules (esomeprazole magnesium) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Calls for greater pharmacist role in prescription drug dependency
RPS Wales haswelcomed areportcalling for NHS Wales to make better use of the expertise of pharmacists in cases ofprescriptiondrug dependence and withdrawal. The report is theresult of evidence gath (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

FDA Approves Sunosi (solriamfetol) for Excessive Daytime Sleepiness Associated with Narcolepsy or Obstructive Sleep Apnea
DUBLIN, March 20, 2019 /PRNewswire/ -- Jazz Pharmaceuticals plc today announced that the U.S. Food and Drug Administration (FDA) approved Sunosi (solriamfetol) to improve wakefulness in adult patients with excessive daytime sleepiness associated... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 21, 2019 Category: Drugs & Pharmacology Source Type: news

Researchers identify potential new combination treatment for pancreatic cancer
FINDINGSResearchers from UCLA ’s Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world’s deadliest cancers. The combination approach uses one drug that inhibits the process — known as lysosome — that allows cancer cells to recycle essential nutrients to survive, and another drug that blocks the pathway used to repair DNA. Researchers found the approach to be promising after testing it on pancreatic cancer cells and mice in the laboratory.BACKGROUNDPancreatic cancer, which is the third leading cause...
Source: UCLA Newsroom: Health Sciences - March 20, 2019 Category: Universities & Medical Training Source Type: news

Calcium Gluconate Injection (Updated - Resolved)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Cefotaxime Sodium (Claforan) Injection (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Vincristine Sulfate (VINCASAR PFS) Injection, USP (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Phendimetrazine Tartrate (Phendimetrazine Tartrate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Trazimera (Trastuzumab-qyyp) for Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Enablex (Darifenacin Extended-Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 20, 2019 Category: Drugs & Pharmacology Source Type: news

Vedolizumab Levels and Outcomes in Ulcerative Colitis Vedolizumab Levels and Outcomes in Ulcerative Colitis
This study aimed to characterize the relationship between vedolizumab exposure and response in ulcerative colitis, adjusted for variables known to affect drug clearance and serum concentration.Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 20, 2019 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Older patients with Crohn's disease benefit from new medications
(Wiley) Combining medications that suppress the immune system has been successful in treating young patients with Crohn's disease, but some physicians have been reluctant to use this strategy in older patients because of concerns about safety. Now an Alimentary Pharmacology& Therapeutics study indicates that older patients can be safely and effectively treated with such combined immunosuppression as well. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 20, 2019 Category: International Medicine & Public Health Source Type: news

FDA Approves Zulresso (brexanolone) for the Treatment of Postpartum Depression
March 19, 2019 -- The U.S. Food and Drug Administration today approved Zulresso (brexanolone) injection for intravenous (IV) use for the treatment of postpartum depression (PPD) in adult women. This is the first drug approved by the FDA... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 19, 2019 Category: Drugs & Pharmacology Source Type: news

Company-led recall: Ozurdex 700 micrograms intravitreal implant in applicator (dexamethasone)
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a company-led recall for further batches of Ozurdex 700 micrograms intravitreal implant in applicator (dexamethasone) due to t (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - March 19, 2019 Category: Drugs & Pharmacology Source Type: news

GARDP and Evotec announce new partnership to discover novel antibiotics
(Drugs for Neglected Diseases Initiative) The Global Antibiotic Research and Development Partnership (GARDP) and Evotec AG have formed a new strategic public-private partnership to tackle the growing threat of antimicrobial resistance. By joining forces, Evotec and GARDP will leverage their capabilities and networks to address drug-resistant bacterial infections. This includes bringing together GARDP's clinical expertise and sustainable access commitment with Evotec's leading drug discovery platform, expertise in medicinal chemistry and pharmacology as well as its world-leading collection of bacterial pathogens. (Source: E...
Source: EurekAlert! - Social and Behavioral Science - March 19, 2019 Category: International Medicine & Public Health Source Type: news

FDA Approves Genentech ’s Tecentriq in Combination With Chemotherapy for the Initial Treatment of Adults With Extensive-Stage Small Cell Lung Cancer
South San Francisco, CA -- March 18, 2019 -- Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), today announced that the U.S. Food and Drug Administration (FDA) approved Tecentriq (atezolizumab), in combination with carboplatin and... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Phone Intervention for Patients Most At Risk Improves HbA1c Phone Intervention for Patients Most At Risk Improves HbA1c
Pharmacist-led phone interventions to improve insulin adherence in patients with diabetes worked best when those at highest risk of noncompliance were targeted.Medscape Medical News (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - March 18, 2019 Category: Drugs & Pharmacology Tags: Diabetes & Endocrinology News Source Type: news

Allergan Announces FDA Approval of Avycaz (ceftazidime and avibactam) for Pediatric Patients
DUBLIN, March 18, 2019 /PRNewswire/ -- Allergan plc (NYSE: AGN) today announced that the U.S. Food and Drug Administration (FDA) has approved the company's supplemental New Drug Application (sNDA) for Avycaz (ceftazidime and avibactam),... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Aminosalicylate Use in Patients With UC on Biologics Aminosalicylate Use in Patients With UC on Biologics
Is it efficacious and cost-effective to continue aminosalicylates in patients with ulcerative colitis who have been escalated to immunosuppressants, biologics, or oral small molecules?Alimentary Pharmacology & Therapeutics (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - March 18, 2019 Category: Allergy & Immunology Tags: Gastroenterology Journal Article Source Type: news

Zostavax (Zoster Vaccine Live) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Namenda (Memantine HCL) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

lidocaine and prilocaine (EMLA)
Title: lidocaine and prilocaine (EMLA)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 3/18/2019 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Tambocor (Flecainide) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Romazicon (Flumazenil) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 18, 2019 Category: Drugs & Pharmacology Source Type: news

Apresoline (Hydralazine) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 18, 2019 Category: Drugs & Pharmacology Source Type: news