NIH Research Festival Plenary Session I - Super enhancers in cell identity and disease
Super enhancers, as the name may connote, offer seemingly heroic regulation of gene expression. While snippets of DNA known as enhancers have long been appreciated to bind with transcription factors to ramp up gene activity, regions of DNA called super enhancers are exceptionally busy parts of the genome that control lineage-defining genes — to paraphrase the movie Spinal Tap, they turn their volume up to 11 just when that extra push is needed. Mutations in super enhancers have been noted in various diseases, and they may play important roles in the dysregulation of gene expression in cancer.
NIH researchers have been at...
Source: Videocast - All Events - September 12, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Persistent Effect of Intensive Glycemic Control on Diabetic Retinopathy in Type 2 Diabetes and 2) Dysglycemia, Vasculopenia, and the Chronic Consequences of Diabetes
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 9/28/2016 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 29, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
How to make pancreatic beta cells for diabetics
Wednesday Afternoon Lecture Series
Dr. Melton is interested in the developmental biology of the pancreas and in understanding the stem cells that give rise to the pancreas. In the lecture, he will discuss the challenges of making stem-cell-derived pancreatic beta cells. A primary problem for insulin-dependent diabetics is the absence (in type 1 diabetes) or dysfunction (in type 2 diabetes) of pancreatic beta cells. The ability to direct the differentiation human stem cells into beta cells opens up the possibility of using these cells for research into the causes of beta-cell loss. In addition, stem-cell-derived beta cell...
Source: Videocast - All Events - January 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Data-Driven Precision Medicine
National Library of Medicine Informatics Lecture Series
There is an urgent need to translate genome-era discoveries into clinical utility, but the difficulties in making bench-to-bedside translations have been well described. The nascent field of translational bioinformatics may help. Dr. Butte's lab builds and applies computational tools to convert hundreds of trillions of points of molecular, clinical, and epidemiological data collected by researchers and clinicians worldwide over the past decade, now commonly known as “big data”, into new diagnostics, therapeutics, and insights into rare and common diseases. Dr. Bu...
Source: Videocast - All Events - May 6, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Unraveling the multi-generational syndrome of diabetic embryopathy: from cell signaling to clinical care
Wednesday Afternoon Lecture Series
Successful fetal and maternal outcomes in the context of maternal pregestational diabetes (type 1 or type 2) largely depend on how well glycemic control is maintained, especially prior to conception and in the first trimester of pregnancy. Stringent metabolic control and monitoring, and nutritional management via supplements and antioxidants significantly reduce the risk for or can eliminate poor outcomes due to hyperglycemia on both the maternal and fetal side.
Experiments in animal models have shown that hyperglycemia induces oxidative stress within the developing cells and tissues ...
Source: Videocast - All Events - April 27, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Inflammation, dysbiosis and chronic disease
Wednesday Afternoon Lecture Series
Dysregulation of the immune system and host-microbiota interaction has been associated with the development of a variety of inflammatory as well as metabolic diseases such as obesity and diabetes. Recent studies in Dr. Flavell's laboratory have elucidated the important function of inflammasomes as steady-state sensors and regulators of the gut microbiota. Mice with a disrupted inflammasome pathway have been shown to develop a colitogenic microbial community, which results in exacerbation of chemical-induced colitis and diet-induced steatohepatitis, obesity and type 2 diabetes.
These d...
Source: Videocast - All Events - March 17, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Vivian Fonseca, MD - Refining Type 2 Diabetes Management: Hitting the Right Glycemic Targets With Long-Acting GLP-1 Receptor Agonists
Refining Type 2 Diabetes Management: Hitting the Right Glycemic Targets With Long-Acting GLP-1 Receptor Agonists (Source: PeerView CME/CE Video Podcast - Endocrinology)
Source: PeerView CME/CE Video Podcast - Endocrinology - April 2, 2014 Category: Endocrinology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
(1) Sickle Cell Anemia: Yesterday, Today, and Tomorrow (2) Epidemiology of Type 2 Diabetes Mellitus: Its History and Contributions to Treatment and Prevention
Presented by: (1) Griffin P. Rodgers, MD, Director, NIDDK (2) Peter H. Bennett, MBchB, Scientist Emeritus, Phoenix Epidemiology and Clinical Research Branch, NIDDKCategory: Clinical Center Grand RoundsAired date: 10/30/2013 (Source: Videocast - All Events)
Source: Videocast - All Events - October 31, 2013 Category: Journals (General) Tags: Past Events Source Type: video
(1) Sickle Cell Anemia: Yesterday, Today, and Tomorrow (2) Epidemiology of Type 2 Diabetes Mellitus: Its History and Contributions to Treatment and Prevention
For more information go to http://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 10/30/2013 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 25, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
Ubiquitination and deubiquitination: a Yin-Yang cycle in protein quality control at the endoplasmic reticulum
Director's Seminar Series
The endoplasmic reticulum (ER) is the major site of protein biosynthesis in eukaryotes. Polypeptides entering the ER frequently encounter folding problems, resulting in aggregation-prone, misfolded proteins. To preserve ER homeostasis, eukaryotic cells have evolved a conserved quality control pathway termed ER-associated protein degradation (ERAD) or retrotranslocation, which eliminates unwanted proteins of the ER by exporting them into the cytosol for degradation by the ubiquitin proteasome system. Defects in ERAD result in accumulation of misfolded proteins and cause ER stress. ER stress has be...
Source: Videocast - All Events - February 19, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video
