The dual PDE3/PDE4 phosphodiesterase inhibitor RPL554 produces more complete bronchodilator responses than the beta2-agonist salbutamol and the anti-muscarinic agent ipratropium bromide, alone and in combination, in guinea-pig isolated trachea
Conclusion . RPL554 has the clinical potential to produce additional bronchodilation over and above that of standard bronchodilators in highly constricted airways. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Venkatasamy, R., Page, C., Spina, D. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research
The 12 Leads of Christmas: aVR
Conclusion to 83 Year Old Male: Shortness of Breath (My earlier primer on diffuse subendocardial ischemia)
A Non STEMI That Needs the Cath Lab Now (Post by Dr. Smith that covers the management of emergent NSTEMI’s)
Five Primary Patterns of Ischemic ST depression, without ST elevation. (Amazing post by Dr. Smith on patterns of ST-depression)
Marked ST depression refractory to maximal medical therapy (More NSTEMI goodness from Dr. Smith)
ST elevation in aVR, with widespread ST depression (Another NSTEMI that needs the cath lab)
Deep and widespread ST depression signifies high risk coronary lesion (One final NSTEMI that...
Source: EMS 12-Lead - December 31, 2014 Category: Cardiology Authors: Vince DiGiulio Tags: 12-Leads of Christmas Original Articles Vince DiGiulio Source Type: research
Drug-drug interactions in cardiothoracic intensive care unit of a pulmonary teaching hospital
Conclusions: Severity and drug combinations related to DDIs in the cardiothoracic ICU differ from other ICU settings. Knowledge of the epidemiology of drug interactions may help clinical practitioners to reduce the risk of adverse drug events. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Baniasadi, S., Bastani, M., Farzanegan, B. Tags: 1.13 Clinical Problems - Other Source Type: research
Inhalation toxicity of soman vapor in non-anesthetized rats: A preliminary assessment of inhaled bronchodilator or steroid therapy.
This study exposed male Sprague-Dawley rats (250-300g) to 520, 560, 600, 825 or 1410mg×min/m(3) of soman in a customized head-out inhalation system. Signs of CWNA-induced cholinergic crises were observed in all soman-exposed animals. The LCt50 of vaporized soman as determined by probit analysis was 593.1mg×min/m(3). All animals exposed to 825 and 1410mg×min/m(3) developed severe convulsions and died within 4-8min post-exposure. Edema measured by wet/dry weight ratio of the left lung lobe increased in a dose-dependent manner in all soman-exposed animals. Bronchoalveolar lavage (BAL) fluid and blood acetylcholinesterase (...
Source: Chemico-Biological Interactions - July 23, 2013 Category: Molecular Biology Authors: Perkins MW, Wong B, Rodriguez A, Devorak JL, Alves DA, Murphy G, Sciuto AM Tags: Chem Biol Interact Source Type: research
The effect of bronchodilators administered via aerochamber or a nebulizer on inspiratory lung function parameters
Conclusions: The present study demonstrates that ILPs improved significantly after using either device. Although significant correlations were found between the VAS and FIF50 and PIF for the nebulizer, in stable COPD patients, the pMDI plus spacer is a better route of administration than a nebulizer. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 14, 2013 Category: Respiratory Medicine Authors: S.K. Ramlal, F.J. Visser, W.C.J. Hop, P.N.R. Dekhuijzen, Y.F. Heijdra Tags: COPD Source Type: research
