Efficacy Of Ipratropium Bromide/Albuterol Compared To Home Metered-Dose Inhalers For Inpatient Management Of Asthmatics
Many patients with asthma require frequent inhaler treatments despite being admitted for non-respiratory causes. Given extensive use of ipratropium bromide/albuterol nebulizer (Duoneb), this study compares clinical outcomes between Duoneb and home Metered Dose Inhalers (MDIs) regimen. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - February 1, 2024 Category: Allergy & Immunology Authors: Valerie Jaroenpuntaruk, Elizabeth Ender, Jamie Sturgill Source Type: research
Atomization efficacy of a novel micro-dose mesh nebulizer (CVS-100) versus the traditional mesh nebulizer (M102) in adults with chronic obstructive pulmonary disease: A randomized non-inferiority clinical trial
CONCLUSION: The novel micro-dose mesh nebulizer (CVS-100) was found to be non-inferior to the traditional mesh nebulizer (M102) in terms of the change in FEV1%pred from baseline after nebulization. Similar results were observed for all other measures of efficacy.PMID:37879448 | DOI:10.1016/j.rmed.2023.107434 (Source: Respiratory Care)
Source: Respiratory Care - October 25, 2023 Category: Respiratory Medicine Authors: Yulan Qu Ying Gong Li Li Yansha Song Yuanlin Song Dongni Hou Lijuan Hu Source Type: research
Comparison of aerosol delivery of AccuMist and AeroEclipse II using a breath simulator
Conclusions: AccuMist delivered a higher dose of drug compared to AeroEclipse II in both the continuous and breath actuated modes. This was true for both Adult and Child Cycles of breath simulator. In one instance where the total dose was lower, the results were not statistically significant. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Toddywala, R., Hande, A., Shukla, V., Newhouse, M. Tags: Acute critical care Source Type: research
Table: Correct Use of Inhalers for COPD (online only)
Date: September 7, 2020
Issue #:
1606Summary:
View the Table: Correct Use of Inhalers for COPD (Source: The Medical Letter)
Source: The Medical Letter - August 31, 2020 Category: Drugs & Pharmacology Authors: admin Tags: aclidinium Advair Aerospan AirDuo Albuterol Alvesco Anoro Ellipta ArmonAir Arnuity Ellipta Asmanex Asthma Atrovent Beclomethasone Bevespi Aerosphere Breo Ellipta Breztri Aerosphere Budesonide ciclesonide Combivent COP Source Type: research
Comparison Table: Inhaled Short-Acting Bronchodilators for Treatment of COPD (online only)
Date: September 7, 2020
Issue #:
1606Summary:
View the Comparison Table: Inhaled Short-Acting Bronchodilators for Treatment of COPD (Source: The Medical Letter)
Source: The Medical Letter - August 31, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Albuterol Atrovent Combivent COPD Ipratropium Levalbuterol ProAir ProAir RespiClick Proventil Salbutamol Xopenex Source Type: research
Strategies to conserve salbutamol pressurized metered-dose inhaler stock levels amid COVID-19 drug shortage
AbstractEssential inhaler medications for patients with respiratory diseases are backordered due to the coronavirus disease of 2019 (COVID-19). In hospitals, there has been a drastic increase in the use of salbutamol pressurized metered-dose inhalers (pMDIs), as well as salbutamol Diskus, leading to a decline in availability and causing interruptions in the supply chain. Patients with asthma are at higher risk of respiratory complications if they are infected with COVID-19. Salbutamol, a short-acting β-agonist (SABA), could be a life-saving medication during critical conditions. Other short-acting muscarinic antagonists (...
Source: Drugs and Therapy Perspectives - July 24, 2020 Category: Drugs & Pharmacology Source Type: research
Aerosol delivery through an endotracheal tube in a model of a spontaneously breathing child
Conclusion: Using standard pediatric dosage, the nebulizer delivered 5 to 7-fold more albuterol than the pMDI or the soft mist inhaler. Placing the nebulizer distal to the endotracheal tube reduced delivery by 56% but was still superior to other devices. The use of the assisted technique did not improve drug delivery. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Berlinski, A., Tucker, M. Tags: Neonatology and paediatric intensive care Source Type: research
Albuterol delivery by soft mist and pressurized metered dose inhalers during noninvasive ventilation in a model of a spontaneously breathing child
Conclusion: Albuterol delivery during NIV with a single-limb ventilator circuit in a model of a spontaneously breathing child using pMDI/SMI is inefficient and is not a cost-efficient when compared to nebulization. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Berlinski, A., Velasco, J. Tags: Neonatology and paediatric intensive care Source Type: research
The effects of respiratory inhaled drugs on the prevention of acute mountain sickness
Background:
Acute mountain sickness (AMS) is common in high-altitude travelers, and may lead to life-threatening high-altitude cerebral edema (HACE) or high-altitude pulmonary edema (HAPE). The inhaled drugs have a much lower peak serum concentrations and a shorter half-life period than oral drugs, which give them a special character, greater local effects in the lung. Meanwhile, short-term administration of inhaled drugs results in almost no adverse reactions.
Methods:
We chose inhaled ipratropium bromide/salbutamol sulfate (combivent, COM), budesonide (pulmicortrespules, BUD), and salbutamol sulfate (ventolin, VEN) ...
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Delivery of Respimat Soft Mist inhaler (SMI) from a Valved Holding Chamber (VHC)
Conclusions: The small differences in FPM between the SMI and SMI+ VHC were within the typical magnitude of method variability. Healthcare providers can have assurance that the use of the SMI with AC+FV VHC should deliver a similar FPM of API compared to the SMI alone.C (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Kushnarev, V., Nagel, M., Doyle, C., Suggett, J. Tags: Airway Pharmacology and Treatment Source Type: research
Assessment of a ventilator circuit adapter to be used in conjunction with the Respimat* Soft Mist Inhaler (SMI)
Conclusions: Approximately 30% LC of both drug components in the SMI was delivered to the distal end of ET tube via the adapter. The presence of a self-sealing valve and safety cap for the adapter should ensure ventilator circuit integrity and therefore also help protect the safety of the patient. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Suggett, J., Nagel, M. Tags: Acute Critical Care Source Type: research
In vitro evaluation of aerosolized delivery of various medications during mechanical ventilation
Conclusions: Vibrating mesh nebulizer generated significant delivered greater drug dose at the Y with less difference, placing at both nebulizers at the inlet of ventilator humidifier. Drug formulation influenced amounts of aerosol delivered passing through the endotracheal tube in a heated mechanical ventilator system. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Fang, T.-P., Lin, H.-L., Wan, G.-H., Tsai, Y.-H., Wang, S.-H. Tags: Airway Pharmacology and Treatment Source Type: research
Quantifying the importance of inhaler attributes corresponding to items in the patient satisfaction and preference questionnaire in patients using Combivent Respimat
Physicians consider ease of use, satisfaction, and preferences when prescribing an inhaler device. These factors may impact appropriate usage and compliance. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - October 16, 2017 Category: International Medicine & Public Health Authors: Kimberly H. Davis, Jun Su, Juan Marcos Gonz ález, Jeremiah J. Trudeau, Lauren M. Nelson, Brett Hauber and Kelly A. Hollis Tags: Research Source Type: research
Efficiency of Ipratropium Bromide and Albuterol Deposition in the Lung Delivered via a Soft Mist Inhaler or Chlorofluorocarbon Metered‐Dose Inhaler
The propellant‐free Combivent Respimat Soft Mist Inhaler (CVT‐R) was developed to replace the chlorofluorocarbon‐propelled Combivent metered‐dose inhaler (CVT‐MDI). This steady‐state pharmacokinetic (PK) substudy evaluated drug lung‐delivery efficiency, using data from two phase III safety and efficacy trials. PK parameters were obtained from well‐controlled population PK analyses. Area under the plasma concentration–time curve (AUC), maximum observed plasma concentration (Cmax), and minimum observed plasma concentration (Cmin) showed systemic exposure to ipratropium bromide and albuterol delivered via th...
Source: Clinical and Translational Science - March 6, 2016 Category: Biomedical Science Authors: TR MacGregor, R ZuWallack, V Rubano, MA Castles, H Dewberry, M Ghafouri, CC Wood Tags: ARTICLE Source Type: research
Exertional dyspnea relief following bronchodilation in COPD: Role of neural respiratory drive
We hypothesized that exertional dyspnea relief following acute bronchodilation in COPD reflects the awareness of reduced neural respiratory drive. In a randomized double-blind crossover study, 20 patients (13 men) aged 68.0±1.5 yrs (mean±SE) with GOLD stage II-IV COPD (FEV1=50±3% predicted) performed four 3-min stair stepping tests at 14, 16, 20 and 24 steps/min (externally paced) after inhalation of nebulized placebo or Combivent® (500 µg ipratropium bromide/2.5 mg salbutamol). Assessments of dyspnea, ventilation (VE), breathing pattern, dynamic operating lung volumes, crural diaphragm EMG a...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Wilkinson-Maitland, C., Borel, B., Perrault, H., Hamilton, A., Bourbeau, J., Maltais, F., Jensen, D. Tags: 4.1 Clinical respiratory physiology, exercise and functional imaging Source Type: research
