Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial)
AbstractObjectivesTo assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged 65 or more with recent symptomatic SARS-CoV-2 infection (COVID-19) and no criteria for hospitalisation.Trial designPhase III, multi-arm (5) and multi-stage (MAMS), randomized, open-label controlled superiority trial.Participants will be randomly allocated 1:1:1:1:1 to the following strategies:Arm 1: Control armArms 2 to 5: Experimental treatment armsPlanned interim analyses will be conducted at regular intervals. Their results will be reviewed by an Independent Data and Safety Monitoring Board. Experime...
Source: Trials - October 13, 2020 Category: Research Source Type: clinical trials
Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease
Condition: Parkinson Disease Interventions: Drug: Citalopram 20mg; Drug: Placebo Sponsors: University of Michigan; National Institute on Aging (NIA) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 4, 2020 Category: Research Source Type: clinical trials
Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers
Condition: Gastroesophageal Reflux Interventions: Drug: Citalopram; Drug: Placebo Sponsor: Universitaire Ziekenhuizen Leuven Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 21, 2020 Category: Research Source Type: clinical trials
Citalopram and Self Emotional Processing
Conditions: Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mental Disorder; Antidepressive Agents; Cognition Interventions: Drug: Citalopram; Drug: Placebo oral tablet Sponsors: University of Oxford; University of Bath Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 19, 2019 Category: Research Source Type: clinical trials
