Dextrin-assisted gel electromembrane extraction of chiral drugs: Improving the extraction efficiency and investigation of enantioselectivity of extraction
Talanta. 2024 Apr 4;274:126016. doi: 10.1016/j.talanta.2024.126016. Online ahead of print.ABSTRACTThe present study investigates the use of dextrins (maltodextrin, β-cyclodextrin, and hydroxypropyl-β-cyclodextrin) to improve the efficiency of the agarose-based gel electromembrane extraction technique for extracting chiral basic drugs (citalopram, hydroxyzine, and cetirizine). Additionally, it examines the enantioselectivity of the extraction process for these drugs. To achieve these, dextrins were incorporated into either the sample solution, the membrane, or the acceptor solution, and then the extraction procedure was p...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Mustafa Alawadi Ali Reza Fakhari Majid Maghsoudi Saeed Nojavan Source Type: research
Dextrin-assisted gel electromembrane extraction of chiral drugs: Improving the extraction efficiency and investigation of enantioselectivity of extraction
Talanta. 2024 Apr 4;274:126016. doi: 10.1016/j.talanta.2024.126016. Online ahead of print.ABSTRACTThe present study investigates the use of dextrins (maltodextrin, β-cyclodextrin, and hydroxypropyl-β-cyclodextrin) to improve the efficiency of the agarose-based gel electromembrane extraction technique for extracting chiral basic drugs (citalopram, hydroxyzine, and cetirizine). Additionally, it examines the enantioselectivity of the extraction process for these drugs. To achieve these, dextrins were incorporated into either the sample solution, the membrane, or the acceptor solution, and then the extraction procedure was p...
Source: Talanta - April 10, 2024 Category: Chemistry Authors: Mustafa Alawadi Ali Reza Fakhari Majid Maghsoudi Saeed Nojavan Source Type: research
Development of an innovative analytical method for forensic detection of cocaine, antidepressants, and metabolites in postmortem blood using magnetic nanoparticles
This study focused on developing an innovative analytical method for the determination of cocaine, antidepressants, and their related metabolites in postmortem blood samples, using unmodified commercial Fe3O4 nanoparticles as a sorbent for dispersive magnetic solid-phase extraction (m-d-SPE), coupled with liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) analysis. An aliquot of 100 µL of whole blood and 5 µL of the internal standard pool were added to 30 mg of nanoparticles. The nanoparticles were separated from the sample using a neodymium magnet inserted into a 3D-printed microtube rack. The liquid...
Source: Analytical and Bioanalytical Chemistry - April 4, 2024 Category: Chemistry Authors: Patricia de Souza Schwarz Bruno Pereira Dos Santos Let ícia Birk Sarah Eller Tiago Franco de Oliveira Source Type: research
Development of an innovative analytical method for forensic detection of cocaine, antidepressants, and metabolites in postmortem blood using magnetic nanoparticles
This study focused on developing an innovative analytical method for the determination of cocaine, antidepressants, and their related metabolites in postmortem blood samples, using unmodified commercial Fe3O4 nanoparticles as a sorbent for dispersive magnetic solid-phase extraction (m-d-SPE), coupled with liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) analysis. An aliquot of 100 µL of whole blood and 5 µL of the internal standard pool were added to 30 mg of nanoparticles. The nanoparticles were separated from the sample using a neodymium magnet inserted into a 3D-printed microtube rack. The liquid...
Source: Analytical and Bioanalytical Chemistry - April 4, 2024 Category: Chemistry Authors: Patricia de Souza Schwarz Bruno Pereira Dos Santos Let ícia Birk Sarah Eller Tiago Franco de Oliveira Source Type: research
Citalopram, an antipsychotic agent, induces G1/G0 phase cell cycle arrest and promotes apoptosis in human laryngeal carcinoma HEP-2 cells
AbstractHuman laryngeal squamous carcinoma (LSCC) is a common malignant tumor in the head and neck. Despite the recently developed therapies for the treatment of LSCC, patients ’ overall survival rate still did not enhance remarkably; this highlights the need to formulate alternative strategies to develop novel treatments. The antitumor effects of antidepressant drugs such as citalopram have been reported on several cancer cells; however, they have yet to be investigated against LSCC. The current study was directed to explore the possible antitumor effects of citalopram on human laryngeal carcinoma cell lines (HEP-2). HE...
Source: Medical Oncology - April 4, 2024 Category: Cancer & Oncology Source Type: research
Use of antidepressants in the treatment of chronic orofacial pain caused by temporomandibular disorders: A randomized controlled clinical trial
CONCLUSIONS: Low doses of amitriptyline appear to be a good therapeutic option in patients with TMDs suffering from chronic orofacial pain.PMID:38570297 | DOI:10.1016/j.medcli.2024.02.002 (Source: Medicina Clinica)
Source: Medicina Clinica - April 3, 2024 Category: General Medicine Authors: Bruno Macedo de Sousa Antonio L ópez-Valverde Francisco Caramelo Maria Joao Rodrigues Nansi L ópez-Valverde Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Psychiatry Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: Clinical Breast Cancer - March 30, 2024 Category: Cancer & Oncology Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: Clinical Genitourinary Cancer - March 30, 2024 Category: Cancer & Oncology Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: Cancer Control - March 30, 2024 Category: Cancer & Oncology Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Psychiatry Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: Clinical Breast Cancer - March 30, 2024 Category: Cancer & Oncology Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case-control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case-control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have brea...
Source: Clinical Genitourinary Cancer - March 30, 2024 Category: Cancer & Oncology Authors: Dian-Jeng Li Shih-Jen Tsai Tzeng-Ji Chen Chih-Sung Liang Mu-Hong Chen Source Type: research
Exposure to psychotropic drugs and breast cancer risk in patients with bipolar disorder and major depressive disorder: a nested case –control study
This study aimed to assess such risk among women with major depressive disorder (MDD) and bipolar disorder (BD). A nested case –control study design was used with data obtained from the Taiwan National Health Insurance Research Database. Logistic regression analysis with adjustments for demographic characteristics, medical and mental comorbidities, and all-cause clinical visits was performed to estimate the risk of breast cancer according to the cumulative defined daily dose (cDDD) of psychotropic drugs. The study included 1564 women with MDD or BD who had breast cancer, and 15,540 women with MDD or BD who did not have b...
Source: European Archives of Psychiatry and Clinical Neuroscience - March 30, 2024 Category: Neuroscience Source Type: research
