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Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging. Senescent Cells Fail to Maintain Proteostasis https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/ Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pl...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

MYSM1 Overexpression Extends Life in Mice via a Reduced Senescent Cell Burden
Senescent cell accumulation is an important cause of degenerative aging. Senescent cells cease replication and begin to secrete an inflammatory mix of signals that disrupt tissue structure and function. These cells are created constantly, largely as a result of somatic cells hitting the Hayflick limit on cellular replication, but also as a result of injury, molecular damage, inflammation, and the like. Near all senescent cells are rapidly destroyed, either via programmed cell death mechanisms, or via the immune system. This clearance falters with age, however, slowing down, becoming less efficient, and allowing senescent c...
Source: Fight Aging! - December 8, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

What pediatricians should know about bone marrow failure syndromes
Pediatricians face a difficult task determining when to refer a child for a suspected bone marrow failure syndrome. We now realize that only a subset of children with bone marrow failure syndromes present with the findings described in textbooks. These children often appear well and lack classical physical stigmata. By the time they look sick, their marrow’s ability to produce blood cells can be so weakened that it could be too late — or at least much more difficult — to treat them successfully. These rare disorders can range from life-threatening conditions requiring a hematopoietic stem cell transplant to...
Source: Kevin, M.D. - Medical Weblog - February 28, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/akiko-shimamura" rel="tag" > Akiko Shimamura, MD, PhD < /a > Tags: Conditions Cancer Source Type: blogs

The Future of Cord Blood Research
You may have heard that the stem cells in your baby’s umbilical-cord blood can save lives, but if you’re like most people, you have only a vague notion of how stem cells work — or which diseases they can treat. Right now, certain cancers, blood disorders, and immune disorders, among other conditions, are being successfully treated with cord-blood stem cells — and thanks to cord blood research, the list of conditions and diseases that may be treated by these stem cells is growing. Why is it important to know about the cord blood research and what types of diseases it can treat? Knowing what cord blood can and...
Source: Cord Blood News - December 15, 2014 Category: Perinatology & Neonatology Authors: joyce at mazelabs.com Tags: babies blood disorder brain development Cord Blood medical research parents pregnancy stem cells affordable cord blood banking bone marrow breast feeding cerebral palsy cord blood banking fees cord blood banking information cor Source Type: blogs