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How Shelterin Solves the Telomere End-Protection Problem
Wednesday Afternoon Lecture Series Dr. de Lange studied biochemistry at the University of Amsterdam and the Netherlands Cancer Institute. As part of her undergraduate training, she worked on globin gene expression at the National Institute for Medical Research (Mill Hill, London). She did her graduate work on the activation and transcription of surface antigen genes in typanosomes. After obtaining her Ph.D. in 1985, she was a postdoctoral fellow with Harold Varmus at the University of California, San Francisco, where she was one of the first to isolate the telomeres of human chromosomes. Telomeres are nucleoprotein comp...
Source: Videocast - All Events - January 8, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video

Connecting Rare and Common Illnesses: Lessons Learned from Dyskeratosis Congenita, the Prototypic Telomere Biology Disorder
Director's Seminar Series Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome classically diagnosed by the presence of the mucocutaneous triad of nail dysplasia, abnormal skin pigmentation, and oral leukoplakia. While the classic triad is not always present, very short leukocyte telomeres are diagnostic of DC and patients with DC have germline mutations in key telomere biology genes. Telomeres, tandem nucleotide repeats and a protein complex at chromosome ends, are essential in preserving genome integrity, shorten with each cell division, and thus are a marker of cellular replicative capa...
Source: Videocast - All Events - October 24, 2013 Category: Journals (General) Tags: Upcoming Events Source Type: video