Sidney Wolfe writes in the BMJ - AllTrials - Selective clinical trial
reporting: betraying trial participants, harming patients
Reporting biases found in trials of cardiovascular devicesReporting biases in published trials were first identified in 1986.1 Published randomized studies of combination chemotherapy compared with treatment with an alkylating agent as first line treatment for ovarian cancer showed a significant survival advantage for combination chemotherapy. Unpublished cancer trial registry data from the same studies, however, showed no such advantage.2 Similarly, in the treatment of multiple myeloma, registry data suggested a smaller survival advantage for combination chemotherapy (over prednisone and an alkylating agent) tha...
Source: PharmaGossip - June 11, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
Sidney Wolfe writes in the BMJ - AllTrials - Selective clinical trial reporting: betraying trial participants, harming patients
Reporting biases found in trials of cardiovascular devicesReporting biases in published trials were first identified in 1986.1 Published randomized studies of combination chemotherapy compared with treatment with an alkylating agent as first line treatment for ovarian cancer showed a significant survival advantage for combination chemotherapy. Unpublished cancer trial registry data from the same studies, however, showed no such advantage.2 Similarly, in the treatment of multiple myeloma, registry data suggested a smaller survival advantage for combination chemotherapy (over prednisone and an alkylating agent) tha...
Source: PharmaGossip - June 11, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
Sidney Wolfe writes in the BMJ - AllTrials - Selective clinical trial
reporting: betraying trial participants, harming patients
Reporting biases found in trials of cardiovascular devicesReporting biases in published trials were first identified in 1986.1 Published randomized studies of combination chemotherapy compared with treatment with an alkylating agent as first line treatment for ovarian cancer showed a significant survival advantage for combination chemotherapy. Unpublished cancer trial registry data from the same studies, however, showed no such advantage.2 Similarly, in the treatment of multiple myeloma, registry data suggested a smaller survival advantage for combination chemotherapy (over prednisone and an alkylating agent) tha...
Source: PharmaGossip - June 10, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
Sidney Wolfe writes in the BMJ - AllTrials - Selective clinical trial
reporting: betraying trial participants, harming patients
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Source: PharmaGossip - June 10, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
Read it and weep - then get angry!
The Deadly Corruption of Clinical TrialsUpdate (4/3/2015): After nearly 11 years of obfuscation and denial surrounding the tragic death of Dan Markingson, the University of Minnesota has suspended enrollment in psychiatric drug trials. This comes in response to a blistering report issued by the Minnesota State Legislative Auditor that cites "serious ethical issues" and vindicates much of the reporting in the story below. Read more from Carl Elliott about the fallout from the report here.IT'S NOT EASY TO WORK UP a good feeling about the institution that destroyed your life, which may be why Mary Weiss i...
Source: PharmaGossip - April 4, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
Read it and weep - then get angry!
The Deadly Corruption of Clinical TrialsUpdate (4/3/2015): After nearly 11 years of obfuscation and denial surrounding the tragic death of Dan Markingson, the University of Minnesota has suspended enrollment in psychiatric drug trials. This comes in response to a blistering report issued by the Minnesota State Legislative Auditor that cites "serious ethical issues" and vindicates much of the reporting in the story below. Read more from Carl Elliott about the fallout from the report here.IT'S NOT EASY TO WORK UP a good feeling about the institution that destroyed your life, which may be why Mary Weiss i...
Source: PharmaGossip - April 3, 2015 Category: Pharmaceuticals Authors: insider Source Type: blogs
If you have diabetes: NO low blood sugars!
Wheat elimination starts you powerfully on the path to reversing diabetes. We’ve seen it many times and it continues to develop in people who kiss their bagels, pretzels, and processed foods booby-trapped with wheat goodbye.
But, as diabetics become less diabetic–a process that can occur VERY quickly, often within days of removing all wheat products from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started administ...
Source: Wheat Belly Blog - March 28, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle blood sugar diabetes gluten grains hypoglycemia Source Type: blogs
Study Discovers How Avandia and Actos Stimulate Brain to Increase Hunger and Weight Gain
(Source: Diabetes Update)
Source: Diabetes Update - March 27, 2015 Category: Endocrinology Source Type: blogs
Why don’t some parents believe the safety of vaccines?
As a medical student, I strongly support vaccination. It works, it’s safe, and it doesn’t cause autism. But I also understand why many parents don’t believe me and the medical community when we beg them to vaccinate their kids.
Medicine has come a long way from “do no harm.” Now we talk about risks and benefits: and none of our tests, medicines, or procedures are without risks. Increasingly, pharmaceutical companies have been caught concealing those risks from doctors and the public.
Around 2000, Merck (the manufacturer with a monopoly on the MMR vaccine that protects against measles) ...
Source: Kevin, M.D. - Medical Weblog - February 28, 2015 Category: Journals (General) Authors: Vamsi Aribindi Tags: Meds Pediatrics Source Type: blogs
Drugs that block weight loss
Following the Wheat Belly lifestyle of wheat and grain elimination results in weight loss in the majority of people in short order.
But there are exceptions. The exceptions should not be interpreted to mean that this lifestyle does not work; it should initiate a search for why the weight loss effect of wheat and grain elimination is being blocked. Iodine deficiency, for example, is a common cause for failed weight loss, no matter how perfect your diet and how much you exercise.
Another common cause for failed weight loss are prescription drugs and a few over-the-counter drugs. Among the common drugs that will block your...
Source: Wheat Belly Blog - February 15, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle gluten grains prescription drugs Weight Loss Source Type: blogs
Upcoming 11/3/2014 FDA-DOC Meeting; Concerns About FDA Biosimilar Guidance(s)
At this point, I don't think its really necessary for me to repeat too much of the content that is already circulating within the diabetes online community of blogs about the forthcoming Monday, November 3, 2014 meeting from 1:00 pm-4:00 pm ET with the U.S. Food and Drug Administration (FDA). But I WILL say that collectively, over the past year, the diabetes patient community was able to accomplish something truly quite extraordinary. You should know about that, and even better, you also have a chance to participate in that!Specifically, in 2013, the diabetes online community started a petition (see http:...
Source: Scott's Web Log - October 20, 2014 Category: Endocrinology Tags: biogenerics Biosimilar diatribe FDA hypoglycemia Lantus Lilly Sanofi Source Type: blogs
You Say You Want Some Revolutions? - Famed Academic Physician Dr Milton Packer's Endless Alternating Turns as Drug Company Spokesperson and FDA Advisor
Last week, we noted we again discussed the web of conflicts of interest that is draped over medicine and health care, and seems responsible for much of our current health care dysfunction. We have discussed examples of conflicts of interest affecting clinical research, clinical teaching, clinical care, and health care policy. Each time I think we must have cataloged all the useful examples, a striking new one appears.Only a few days later, yet another new variant has in fact appeared. A New Kind of Revolving Door A new version of the "revolving door" apparently was first noted by Public Citizen, and t...
Source: Health Care Renewal - September 16, 2014 Category: Health Management Tags: Avandia Bristol-Myers-Squibb conflicts of interest FDA GlaxoSmithKline Milton Packer Novartis Pfizer revolving doors sacubitril Source Type: blogs
Baron and Budd Announces $177 Million Settlement for Seven States Against Avandia Manufacturer GlaxoSmithKline
DALLAS, Jun 13, 2014 (BUSINESS WIRE) -- The national law firm of Baron and Budd has reached a $177 million settlement with GlaxoSmithKline on behalf of the states of Kentucky, Maryland, Mississippi, New Mexico, South Carolina, Utah and West Virginia regarding the deceptive advertising of the diabetes drug Avandia. This result represents the largest settlement of a pharmaceutical case ever for several of the involved states, and a much higher settlement for each individual state than what they would otherwise have received in a multistate settlement reached in 2012. Baron and Budd attorneys Russell Budd, Burton LeBlanc, Lau...
Source: PharmaGossip - June 13, 2014 Category: Pharma Commentators Authors: insider Source Type: blogs
Deadly Medicines and Organised Crime: a review
This is a web version of a review of Peter Gotzsche’s book. It appeared in the April 2014 Healthwatch Newsletter. Read the whole newsletter. It has lots of good stuff. Their newsletters are here. Healthwatch has been exposing quackery since 1989. Their very first newsletter is still relevant.
Most new drugs and vaccines are developed by the pharmaceutical industry. The industry has produced huge benefits for mankind. But since the Thatcherite era it has come to be dominated by marketing people who appear to lack any conscience. That’s what gave rise to the Alltrials movement. It was founded in January 2...
Source: DC's goodscience - April 16, 2014 Category: Science Authors: David Colquhoun Tags: Academia badscience Big Pharma blogosphere Martin Keller Peter Gotzsche Pharmaceutical Industry Richard Eastell Source Type: blogs
