Immune Tolerance Network (UM1 Clinical Trial Required)
Funding Opportunity RFA-AI-19-068 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Immune Tolerance Network. The major goal of this Network is to develop tolerogenic approaches for the treatment and prevention of disease in three clinical areas: asthma and allergic diseases; autoimmune diseases; and immune-mediated consequences of allotransplantation. The scope of research to be carried out includes: 1) the design and conduct of clinical trials at all phases to evaluate the safety and efficacy of investigational products and approa...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 6, 2019 Category: Research Source Type: funding
ImmuneChip: Engineering Microphysiological Immune Tissue Platforms (U01 Clinical Trial Not Allowed)
Funding Opportunity PAR-19-138 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to promote the development of in vitro platforms that recapitulate components of the human immune system. Applications that qualify for this funding will focus on engineering 3-D in vitro microphysiological immune system tissues, adding immune system responsiveness to existing in vitro platforms, and/or in vitro modeling autoimmune diseases and inflammation. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 27, 2018 Category: Research Source Type: funding
Human Islet Research Network - Consortium on Modeling Autoimmune Interactions (HIRN-CMAI) (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-18-013 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites new and renewal applications to participate in the Consortium on Modeling Autoimmune Interactions (CMAI). CMAI is a component of the Human Islet Research Network (HIRN) that is focused on developing robust systems to measure and model the biology of human type 1 diabetes. Projects will explore and validate research models designed to advance pre-clinical scientific discovery, mechanistic dissection of disease processes, and testing of potential interventions for T1D. (Source: NIH Funding Opp...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 17, 2018 Category: Research Source Type: funding
Human Islet Research Network - Consortium on Modeling Autoimmune Interactions (HIRN-CMAI) (U01 Clinical Trial Not Allowed)
This Funding Opportunity Announcement (FOA) invites new and renewal applications to participate in the Consortium on Modeling Autoimmune Interactions (CMAI). CMAI is a component of the Human Islet Research Network (HIRN) that is focused on developing robust systems to measure and model the biology of human type 1 diabetes. Projects will explore and validate research models designed to advance pre-clinical scientific discovery, mechanistic dissection of disease processes, and testing of potential interventions for T1D.RFA-DK-18-013 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - December 17, 2018 Category: Endocrinology Source Type: funding
Fc-Dependent Mechanisms of Antibody-Mediated Killing (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AI-18-042 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from institutions and organizations to conduct research focused on elucidating mechanisms of Fc-dependent, antibody-mediated killing of infected or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. Studies supported by this FOA are expected to define variables that affect efficiencies of antibody-dependent cellular cytotoxicity (ADCC) and/or antibody-dependent cell-mediated phagocytosi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 5, 2018 Category: Research Source Type: funding
Fc-Dependent Mechanisms of Antibody-Mediated Killing (R21 Clinical Trial Not Allowed)
Funding Opportunity PA-19-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites R21 applications for studies that address knowledge gaps in mechanisms of Fc-dependent, antibody-mediated killing of infected cells or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. More specifically, the purpose of this FOA is to promote innovative and exploratory research to elucidate mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (A...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 5, 2018 Category: Research Source Type: funding
Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-18-011 from the NIH Guide for Grants and Contracts. This FOA invites new applications to participate in the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB). NIDDK will support the development of a microphysiological system (MPS) that allows the study of interactions between primary human islets or assembled islet spheroids (organoids made up of human beta/alpha/delta/other cells) and immune cells within a 3D microenvironment to mimic aspects of the autoimmune process and its regulation. The ultimate goal will be to create an in vitro human disease model(s) that c...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 10, 2018 Category: Research Source Type: funding
Human Islet Research Network - Consortium on Human Islet Biomimetics (HIRN-CHIB) (UG3/UH3 Clinical Trial Not Allowed)
This FOA invites new applications to participate in the Human Islet Research Network-Consortium on Human Islet Biomimetics (HIRN-CHIB). NIDDK will support the development of a microphysiological system (MPS) that allows the study of interactions between primary human islets or assembled islet spheroids (organoids made up of human beta/alpha/delta/other cells) and immune cells within a 3D microenvironment to mimic aspects of the autoimmune process and its regulation. The ultimate goal will be to create an in vitro human disease model(s) that could recapitulate some aspects of the complex pathophysiology of Type 1 diabetes (...
Source: NIDDK Funding Opportunities - August 10, 2018 Category: Endocrinology Source Type: funding
Expanding Extramural Research Opportunities at the NIH Clinical Center (U01 Clinical Trial Optional)
Funding Opportunity PAR-18-879 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support extramural investigator-initiated clinical research in collaboration and partnership with intramural investigators at the NIH Clinical Center in Bethesda, MD. This new FOA will leverage the resources (inpatient and outpatient) and assets of the NIH Clinical Center (e.g., scientific, clinical trial and expertise, nursing, beds, critical care services, ambulatory care services, laboratories, imaging, biostatistics, protocol development, regulatory guidance, clinical trials management and safety oversight) in a...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 26, 2018 Category: Research Source Type: funding
Research to Advance Vaccine Safety (R01 Clinical Trial Not Allowed)
Funding Opportunity PA-18-873 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research that will contribute to the overall understanding of vaccine safety. This research opportunity encourages studies that address scientific areas potentially relevant to vaccine safety, such as: 1) characterization of physiological and immunological responses to vaccines and vaccine components, including different adjuvants; 2) how genetic variations affect immune/physiological responses that may impact vaccine safety; 3) identification of risk factors (e.g., infectio...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 24, 2018 Category: Research Source Type: funding
Research to Advance Vaccine Safety (R21 Clinical Trial Not Allowed)
Funding Opportunity PA-18-872 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research that will contribute to the overall understanding of vaccine safety. This research opportunity encourages studies that address scientific areas potentially relevant to vaccine safety such as 1) characterization of physiological and immunological responses to vaccines and vaccine components, including different adjuvants; 2) how genetic variations affect immune/physiological responses that may impact vaccine safety; 3) identification of risk factors (e.g., infection ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 24, 2018 Category: Research Source Type: funding
Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allowed)
Funding Opportunity RFA-AI-18-002 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to participate in the NIAID Autoimmunity Centers of Excellence (ACE), a cooperative network intended to improve the understanding, prevention, and treatment of autoimmune diseases (www.autoimmunitycenters.org). The ACE was founded on the premise that collaborations among basic and clinical scientists can accelerate both fundamental and applied research. The ACE combines Basic and Clinical research programs. This FOA solicits applications for the Basic resear...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 8, 2018 Category: Research Source Type: funding
Autoimmunity Centers of Excellence, Clinical Research Program (UM1 Clinical Trial Required)
Funding Opportunity RFA-AI-18-003 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to participate in the NIAID Autoimmunity Centers of Excellence (ACE), a cooperative network intended to improve the understanding, prevention, and treatment of autoimmune diseases (www.autoimmunitycenters.org). The ACE program was founded on the premise that collaborations among basic and clinical scientists can accelerate both fundamental and applied research. The ACE combines Basic and Clinical research programs. This FOA solicits applications for the Clin...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 8, 2018 Category: Research Source Type: funding
Immune System Engineering For Targeted Tolerance in Type 1 Diabetes (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DK-17-020 from the NIH Guide for Grants and Contracts. Type 1 diabetes (T1D) results in part from the autoimmune-mediated dysfunction or destruction of insulin-producing pancreatic beta cells. This funding opportunity is for projects that seek to discover ways to change the course of the disease by directly establishing tolerance. Immune responses could be engineered for tolerance induction through the manipulation of antigens, cells, or cellular microenvironments. Collaborations between T1D experts and investigators from other fields, including (but not limited to) cancer immunology and biomater...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 14, 2018 Category: Research Source Type: funding
Career Development Programs in Diabetes Research for Endocrinologists (K12 Clinical Trial Optional)
Funding Opportunity RFA-DK-17-026 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement is intended to foster the development of a diverse and highly trained workforce of endocrinologists to assume leadership roles related to the Nations biomedical and behavioral research efforts in the area of type 1 diabetes (T1D). T1D is an autoimmune disease that occurs in both children and adults. Therefore, the NIDDK will award physician scientist career development program (K12) grants to eligible institutions to provide a program to prepare adult and/or pediatric endocrinologists, selected by the ins...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 14, 2018 Category: Research Source Type: funding
