Amitriptyline Shows Promise as Local Dental AnestheticAmitriptyline Shows Promise as Local Dental Anesthetic
A controlled trial of the antidepressant amitriptyline applied in a mucoadhesive tablet suggests the drug has promise as a topical anesthetic in dentistry. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 11, 2013 Category: Consumer Health News Tags: Dental & Oral Health News Source Type: news
Amitriptyline versus placebo for major depressive disorder
Source: Cochrane
Area: Evidence > Drug Specific Reviews
Background
Amitriptyline is a tricyclic antidepressant that was synthesised in 1960 and introduced as early as 1961 in the USA, but is still regularly used. It has also been frequently used as an active comparator in trials on newer antidepressants and can therefore be called a 'benchmark' antidepressant. However, its efficacy and safety compared to placebo in the treatment of major depression has not been assessed in a systematic review and meta-analysis.
Objectives
To assess the effects of amitriptylin...
Source: NeLM - Mental Health - January 3, 2013 Category: Psychiatry Source Type: news
Amitriptyline for neuropathic pain and fibromyalgia in adults
Source: Cochrane
Area: Evidence > Drug Specific Reviews
Background
Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines. These types of pain can be treated with antidepressant drugs in doses below those at which the drugs act as antidepressants.
Objectives
To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia.To assess the adverse events associated with the clinical use ...
Source: NeLM - Drug Specific Reviews - January 3, 2013 Category: Drugs & Pharmacology Source Type: news
