TIMELAPSE study —efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial
This study will test if treatment with low-dose amitriptyline for insomnia in patients with medical comorbidity is non-inferior to CBT-I in a multicenter randomized controlled non-inferiority trial. Participants will be 190 adults with a long-term medical condition and insomnia. Participants will be randomly allocated to one of two intervention arms: 12 weeks AM (starting with 10 mg per day, and if ineffective at 3 weeks, doubling this dose) or 12 weeks of CBT-I consisting of 6 weekly sessions and a follow-up session 6 weeks later. The primary outcome is subjective insomnia severity, measured with the Insomnia...
Source: Trials - December 11, 2021 Category: Research Source Type: clinical trials
Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough
Condition: Interstitial Lung Disease Interventions: Drug: Amitriptyline 25 MG; Drug: Amitriptyline 50 MG; Drug: Duloxetine 30 MG; Drug: Duloxetine 60 MG; Drug: Placebo 30 MG; Drug: Placebo 60 MG Sponsor: Mayo Clinic Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 16, 2021 Category: Research Source Type: clinical trials
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
Condition: Refractory Chronic Cough Interventions: Drug: Duloxetine 30 MG; Drug: Duloxetine 60 MG; Drug: Amitriptyline 25 MG; Drug: Amitriptyline 50 MG; Drug: Placebo 30 MG; Drug: Placebo 60 MG Sponsor: Mayo Clinic Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 5, 2021 Category: Research Source Type: clinical trials
