Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial
DiscussionThe study includes direct comparisons of the mainstay treatment for DPNP. This novel study is designed to examine treatment pathways and capture clinically relevant outcomes which will make the results generalisable to current clinical practice. The study will also provide information on health economic outcomes and will include a subgroup study to provide information on whether patient phenotypes predict response to treatment.Trial registrationISRCTN17545443. Registered on 12 September 2016. (Source: Trials)
Source: Trials - October 22, 2018 Category: Research Source Type: clinical trials
Bioavailability Study of Amitriptyline Hydrochloride Tablets
Condition: Depressive Disorder Intervention: Drug: Amitriptyline Hydrochloride 25Mg Tablet Sponsors: First Affiliated Hospital of Zhejiang University; Hunan DongtingPharm.Co.Ltd Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 24, 2018 Category: Research Source Type: clinical trials
Bioavailability Study of Amitriptyline Hydrochloride Tablets
Condition: Depressive Disorder Interventions: Drug: Amitriptyline Hydrochloride 25Mg Tablet（Hunan Dongting）; Drug: Amitriptyline Hydrochloride 25Mg Tablet（Sandoz） Sponsors: First Affiliated Hospital of Zhejiang University; Hunan DongtingPharm.Co.Ltd Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 24, 2018 Category: Research Source Type: clinical trials
Bioavailability Study of Amitriptyline Hydrochloride Tablets
Condition: Depressive Disorder Intervention: Drug: Amitriptyline Hydrochloride 25Mg Tablet Sponsors: First Affiliated Hospital of Zhejiang University; Hunan DongtingPharm.Co.Ltd Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 24, 2018 Category: Research Source Type: clinical trials
