A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose ‐regulated protein 78 as a new hepatotrophic factor

ConclusionsThe M2BPGi-activated KCs secrete GRP78, which facilitates liver regeneration and improves the survival in a lethal mice model. Our data suggest that the new hepatotrophic factor GRP78 may be a promising therapeutic tool for lethal liver failure.

Source: Journal of Hepato-Biliary-Pancreatic Sciences - June 1, 2022 Category: Gastroenterology Authors: Kei Hagiwara, Norifumi Harimoto, Takahiro Yamanaka, Norihiro Ishii, Takehiko Yokobori, Mariko Tsukagoshi, Akira Watanabe, Kenichiro Araki, Tomoharu Yoshizumi, Ken Shirabe Tags: ORIGINAL ARTICLE Source Type: research