pHLIP Peptides Target Acidity in Activated Macrophages

ConclusionspHLIP peptides sense low cell surface pH, which triggers their insertion into the cell membrane. Unlike cancerous cells, activated macrophages do not retain inserted pHLIPs on their surfaces, instead their highly active membrane recycling moves the pHLIPs into endosomes. Targeting activated macrophages in diseased tissues may enable clinical visualization and therapeutic opportunities.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research