SIAH1 promotes senescence and apoptosis of nucleus pulposus cells to exacerbate disc degeneration through ubiquitinating XIAP

CONCLUSION: In IDD patients, SIAH1 can target and ubiquitinate XIAP, thereby mediating senescence, apoptosis, increased inflammation, and decreased ECM synthesis of NPCs, while METTL3-mediated m6A can methylate SIAH1 mRNA, producing harmful effects.PMID:35580525 | DOI:10.1016/j.tice.2022.101820

Source: Tissue and Cell - May 17, 2022 Category: Cytology Authors: Shibing Fang Fangjun Zeng Rongchun Chen Mingheng Li Source Type: research