Probiotic sepsis in preterm neonates —a systematic review

Conclusion: Probiotics sepsis is relatively an uncommon event in preterm infants. Majority of the cases recovered after antibiotic or antifungal treatment. The importance of optimal surveillance and treatment of probiotic sepsis and research towards alternatives to probiotics (e.g. postbiotics) is emphasised.What is Known:• Probiotics have been shown to reduce necrotising enterocolitis, late-onset sepsis, all-cause mortality, and time to reach full enteral feeds in preterm infants.• Despite the evidence, use of probiotics is not universal due to concerns regarding probiotic-associated sepsis in preterm infants.What is New:• This comprehensive systematic review showed that probiotic sepsis is a relatively rare phenomenon in preterm infants.• All except one case where the diagnosis was uncertain recovered after antimicrobial therapy.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research