Picropodophyllin inhibits the growth of pemetrexed-resistant malignant pleural mesothelioma via microtubule inhibition and IGF-1R-, caspase-independent pathways

CONCLUSIONS: Picropodophyllin may offer novel therapeutic properties for treating acquired pemetrexed-resistant MPM. Targeting tubulin may be an important strategy in the treatment of MPM after the discontinuation of pemetrexed.PMID:35529797 | PMC:PMC9073748 | DOI:10.21037/tlcr-21-765

Source: Cell Research - May 9, 2022 Category: Cytology Authors: Rong Sun Ryosuke Tanino Xuexia Tong Eshat Fahmida Haque Yoshihiro Amano Takeshi Isobe Yukari Tsubata Source Type: research