Cleft size and type are associated with development of epilepsy and poor seizure control in patients with schizencephaly

Schizencephaly is a rare congenital anomaly with polymicrogyric gray matter-lined clefts [1 –3]. Along with polymicrogyria, schizencephaly belongs to a group of malformations of cortical development occurring at the stage of neuronal organization [2,4]. Patients with malformations of cortical development have a high prevalence of epilepsy, and many cases are medically refractory [5–7]. Although data from precise epidemiological studies are lacking, epilepsy has been reported in 37–74% of patients with schizencephaly [1,8-10].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research