Perioperative Oxidative Stress Prospectively Predicts CRPS-Related Outcomes in the 6 months Following Total Knee Arthroplasty

This project tested whether oxidative stress (OS) related to extended tourniquet application during total knee arthroplasty (TKA) and subsequent ischemic reperfusion contributed to CRPS outcomes up to 6 month following TKA. Blood samples were obtained in 90 osteoarthritis patents (63.3% female; 95.6% Non-Hispanic White) undergoing TKA prior to tourniquet placement (T1), 45 minutes after tourniquet inflation (T2), and 15 minutes following tourniquet removal (T3). Plasma levels of F2-isoprostanes (IsoPs) and isofurans (IsoFs), the most specific measures of in vivo OS, were quantified.

Source: The Journal of Pain - May 1, 2022 Category: Materials Science Authors: Stephen Bruehl, Frederic T. Billings IV, Sara Anderson, Gregory Polkowski, Andrew Shinar, Jonathan Schildcrout, Yaping Shi, Ginger Milne, Anthony Dematteo, Puneet Mishra, R. Norman Harden Tags: 7 Source Type: research