Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats

Toxicon. 2022 Apr 27:S0041-0101(22)00116-7. doi: 10.1016/j.toxicon.2022.04.014. Online ahead of print.ABSTRACTIn this work, we report the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A2 inhibitor - VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal and hepatic morphological alterations.PMID:35489427 | DOI:10.1016/j.toxicon.2022.04.014

Source: Toxicon - April 30, 2022 Category: Toxicology Authors: Rosimeire Silva-Carvalho Matheus Z Gaspar Luiz H B Quadros Lu ís G G Lobo Rog ério Giuffrida Cec ília L Santarém Elisangela O Silva Juliana R Gerez Nelson J Silva Stephen Hyslop Bruno Lomonte Rafael S Floriano Source Type: research