P442. Functional and Structural Connectivity Alterations Associated With 7q11.23 Copy Number Variations

Williams syndrome (WS) and 7q11.23 duplication syndrome (Dup7) are caused by hemideletion or duplication, respectively, of ∼25 genes on chromosomal locus 7q11.23. Previous research has shown altered functional connectivity and white-matter microstructure in WS. After searching across the brain for regions with altered functional connectivity related to 7q11.23 copy number variation (CNV), we tested for alterations in white-matter tracts connecting these regions as a function of gene dosage.

Source: Biological Psychiatry - April 28, 2022 Category: Psychiatry Authors: Zachary Trevorrow, J. Shane Kippenhan, Michael Gregory, Tiffany Nash, Andrea E. Gouvea, Danya Adams, Olivia R. Kline, Daniel Eisenberg, Philip Kohn, Dwight Dickinson, Carolyn B. Mervis, Karen F. Berman Source Type: research