RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages

In this study, we investigated the crosstalk between RANK and TLR4 pathways in macrophages stimulated with both RANKL and LPS to unveil the role of OPG in inflammatory processes. We found that RANKL inhibits TLR4 activation by binding to RANK, promoting the binding between TRAF6 and RANK, lowering TLR4 activation and the expression of proinflammatory mediators. Furthermore, high OPG levels aggravate inflammation by inhibiting RANKL. Our findings elect RANKL as a candidate for drug development as a way to mitigate the impact of obesity-induced inflammation in patients.PMID:35463988 | PMC:PMC9019442 | DOI:10.1155/2022/7740079

Source: Biomed Res - April 25, 2022 Category: Research Authors: Ryerson Fonseca Mota Paulo Henrique Cavalcanti de Ara újo Maria Eduarda Ramos Cezine Fl ávia Sayuri Matsuo Rodrigo Jair Morandi Metzner Carlos Alberto Oliveira de Biagi Junior Kamila Chagas Peronni Hiroki Hayashi Munehisa Shimamura Hironori Nakagami Mar Source Type: research