Postnatal conservation of human blood- and marrow-specific CD34+ hematopoietic phenotypes

Hematopoiesis is a hierarchically organized process enabling the lifelong output of mature blood cells from relatively small numbers of hematopoietic stem cells (HSCs). Nevertheless, there is growing evidence of heterogeneity in how this process is determined and executed throughout life [1 –3]. In humans, HSCs are defined functionally by their retrospectively demonstrated display of a very extensive self-sustaining ability, as revealed using either long-term clonal tracking or serial transplant evidence of sustained peripheral blood (PB) cell output [4–8].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research