Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastro-Retentive Drug Delivery System

The main purpose of the present study was to fabricate the mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as the bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the crosslinking agent. The test samples analyzed via different methods such as XRD, FT-IR, TGA, and SEM. Drug incorporation efficacy and mucoadhesive strength of these nanocomposite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels were evaluated in simulated gastric fluid (SGF, pH 1.2). The optimized MMT-FMT/CH bio-nanocomposite hydrogels displayed a controllable and sustainable drug release profile with suitable mucoadhesion and prolonged retention time in the stomach. Thus, the resultant data demonstrated that the fabricated mucoadhesive bio-nanocomposite hydrogels can remarkably increase the therapeutic efficacy and bioavailability of famotidine (FMT) by oral route.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research