Targeted synthesis of 2-substituted tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one as potential tyrosinase inhibitors

Conclusion: As a result of molecular docking studies, the feasibility of synthesizing 2-substituted tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-4(3H)-one as potential tyrosinose inhibitors was justified. 2-substituted tetrahydrobenzo [4,5]thieno[2,3-d]pyrimidine-4(3H)-one were obtained using new synthesis conditions. The leading compound is 4g containing a fragment of 2,4-dihydroxybenzene.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research