Anti-inflammatory properties of the genus Symphytum L.: A review

The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intention in the signaling pathway, constrain pro-inflammatory enzymes, reduced the construction of inflammatory chemokine’s and cytokines, and decrease oxidative stress, which afterward suppresses inflammation procedures. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. The papers with the English language gathered from 2000 to 2021.This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The Symphytum genus is waiting for researchers for developing safe and effective anti-inflammatory agents for additional investigation other different mechanisms of action.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research