Cerebrospinal fluid kappa free light chains as biomarker in multiple sclerosis —from diagnosis to prediction of disease activity

SummaryMultiple sclerosis (MS) is a  chronic immune-mediated disorder of the central nervous system that shows a high interindividual heterogeneity, which frequently poses challenges regarding diagnosis and prediction of disease activity. In this context, evidence of intrathecal inflammation provides an important information and mig ht be captured by kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF). In this review, we provide an overview on what is currently known about κ‑FLC, its historical development, the available assays and current evidence on its diagnostic and prognostic value in MS. Briefly, intrathe cal κ‑FLC synthesis reaches similar diagnostic accuracy compared to the well-established CSF-restricted oligoclonal bands (OCB) to identify patients with MS, and recent studies even depict its value for prediction of early MS disease activity. Furthermore, detection of κ‑FLC has significant me thodological advantages in comparison to OCB detection.
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research