Simplified 6-month prediction scores for primary biliary cholangitis patients treated with ursodeoxycholic acid

Objectives To develop a prognostic score evaluating treatment response at 6 months after ursodeoxycholic acid (UDCA) initiation in primary biliary cholangitis (PBC) patients. Methods Adult PBC patients who were newly prescribed UDCA at our institution (n = 292) were included. Significant determinants of liver-related adverse events in the multivariable Cox model were used for score development, weighted by β-coefficients. Discrimination ability was assessed using Harrell’s C-statistic. The performance of our model was compared to the previous models. Results Our model included the following variables evaluated at 6 months: (1) alkaline phosphatase decline of less than 50% from baseline and>upper limit normal (ULN) (2 points); (2) bilirubin>ULN (2 points); (3) albumin
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research