Evaluation of a Zingiber officinale and Bixa orellana Supplement on the Gut Microbiota of Male Athletes: A Randomized Placebo-Controlled Trial

Planta Med DOI: 10.1055/a-1671-5766The gut microbiota has emerged as a factor that influences exercise performance
and recovery. The present study aimed to test the effect of a polyherbal
supplement containing ginger and annatto called “ReWin(d)” on the gut microbiota
of recreational athletes in a pilot, randomized, triple-blind,
placebo-controlled trial. Thirty-four participants who practice physical
activity at least three times weekly were randomly allocated to two groups, a
ReWin(d) group or a maltodextrin (placebo) group. We evaluated the gut
microbiota, the production of short-chain fatty acids, and the serum levels of
interleukin-6 and lipopolysaccharide at baseline and after 4 weeks. Results
showed that ReWin(d) supplementation slightly increased gut microbiota
diversity. Pairwise analysis revealed an increase in the relative abundance of
Lachnospira (β-coefficient = 0.013; p = 0.001),
Subdoligranulum (β-coefficient = 0.016; p = 0.016),
Roseburia (β-coefficient = 0.019; p = 0.001), and
Butyricicoccus (β-coefficient = 0.005; p = 0.035) genera in
the ReWin(d) group, and a decrease in Lachnoclostridium
(β-coefficient = − 0.008; p = 0.009) and the Christensenellaceae R7 group
(β-coefficient = − 0.010; p < 0.001). Moreover, the
Christensenellaceae R-7 group correlated positively with serum interleukin-6
(ρ...

Source: Planta Medica - February 28, 2022 Category: Drugs & Pharmacology Authors: Dom ínguez-Balmaseda, Diego Bressa, Carlo Fern ández-Romero, Arantxa de Lucas, Beatriz P érez-Ruiz, Margarita San Juan, Alejandro F. Roller, Marc Issaly, Nicolas Larrosa, Mar Tags: Original Papers Source Type: research