ERK signaling dissolves ERF repression condensates in living embryos [Developmental Biology]

Phase separation underlies the organization of the nucleus, including the biogenesis of nucleoli and the packaging of heterochromatin. Here we explore the regulation of transcription factor condensates involved in gene repression by ERK signaling in gastrulating embryos of a simple proto-vertebrate (Ciona). ERK signaling induces nuclear export of the transcriptional...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Developmental Biology Biological Sciences Source Type: research