Heritable changes in division speed accompany the diversification of single T cell fate [Biophysics and Computational Biology]

Rapid clonal expansion of antigen-specific T cells is a fundamental feature of adaptive immune responses. It enables the outgrowth of an individual T cell into thousands of clonal descendants that diversify into short-lived effectors and long-lived memory cells. Clonal expansion is thought to be programmed upon priming of a single...

Source: Proceedings of the National Academy of Sciences - February 25, 2022 Category: Science Authors: Marten Plambeck, Atefeh Kazeroonian, Dirk Loeffler, Lorenz Kretschmer, Ciro Salinno, Timm Schroeder, Dirk H. Busch, Michael Flossdorf, Veit R. Buchholz Tags: Immunology and Inflammation Biological Sciences Source Type: research