Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor [Biophysics and Computational Biology]
Protein–protein binding domains are critical in signaling networks. Src homology 2 (SH2) domains are binding domains that interact with sequences containing phosphorylated tyrosines. A subset of SH2 domain–containing proteins has tandem domains, which are thought to enhance binding affinity and specificity. However, a trade-off exists between long-lived binding and the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jesse Goyette, David Depoil, Zhengmin Yang, Samuel A. Isaacson, Jun Allard, P. Anton van der Merwe, Katharina Gaus, Michael L. Dustin, Omer Dushek Tags: Immunology and Inflammation Biological Sciences Source Type: research