Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer [Medical Sciences]

In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione peroxidase 2 (GPx2) in oncogenic signaling and patient survival. GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA (vascular endothelial growth factor A) signaling, causing poor perfusion and hypoxia, which were...

Source: Proceedings of the National Academy of Sciences - February 22, 2022 Category: Science Authors: Zuen Ren, Huizhi Liang, Phillip M. Galbo Jr, Malindrie Dharmaratne, Ameya S. Kulkarni, Atefeh Taherian Fard, Marie Louise Aoun, Nuria Martinez-Lopez, Kimita Suyama, Outhiriaradjou Benard, Wei Zheng, Yang Liu, Joseph Albanese, Deyou Zheng, Jessica C. Mar, Tags: Medical Sciences Biological Sciences Source Type: research