Serum/glucocorticoid ‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activated T cell nuclear factor transcription factor 2

In this study, SGK1 targeted TRPV1 to regulate the proliferation of MBSMCs mediated by BOO in mice through NFAT2 and then affected the process of b ladder remodeling after BOO. This finding may provide a strategy for BOO drug target screening.

Source: IUBMB Life - February 21, 2022 Category: Research Authors: Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf Tags: RESEARCH COMMUNICATION Source Type: research