Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera [Systems Biology]
Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues influence pathogenic expression of ECM remodeling genes in tissue-resident valvular myofibroblasts, and the regulation of complex myofibroblast signaling networks depends on patient-specific extracellular factors. Here, we combined a manually curated...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jesse D. Rogers, Brian A. Aguado, Kelsey M. Watts, Kristi S. Anseth, William J. Richardson Tags: Systems Biology Biological Sciences Source Type: research