Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera [Systems Biology]

Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues influence pathogenic expression of ECM remodeling genes in tissue-resident valvular myofibroblasts, and the regulation of complex myofibroblast signaling networks depends on patient-specific extracellular factors. Here, we combined a manually curated...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Systems Biology Biological Sciences Source Type: research