D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 [Medical Sciences]

Breast cancer is the most frequent malignancy in women worldwide, and triple-negative breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The therapeutic strategies for TNBC are limited. It is urgent to develop new methods to enhance the efficacy of TNBC treatment. Previous studies demonstrated that...

Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang, Yanping Xu, Lei Lv Tags: Medical Sciences Biological Sciences Source Type: research