The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution [Neuroscience]

Acute stress leads to sequential activation of functional brain networks. A biologically relevant question is exactly which (single) cells belonging to brain networks are changed in activity over time after acute stress across the entire brain. We developed a preprocessing and analytical pipeline to chart whole-brain immediate early genes’ expression—as...

Source: Proceedings of the National Academy of Sciences - February 18, 2022 Category: Science Authors: Valeria Bonapersona, Heike Schuler, Ruth Damsteegt, Youri Adolfs, R. Jeroen Pasterkamp, Martiȷn P. van den Heuvel, Marian Joels, R. Angela Sarabdȷitsingh Tags: Neuroscience Biological Sciences Source Type: research