LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint [Systems Biology]

Retrotransposons are genomic DNA sequences that copy themselves to new genomic locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon in the human genome. The mobility of LINE-1 is largely repressed in somatic tissues but is derepressed in many cancers, where LINE-1 retrotransposition is correlated with p53...

Source: Proceedings of the National Academy of Sciences - February 15, 2022 Category: Science Authors: Wilson McKerrow, Xuya Wang, Carlos Mendez–Dorantes, Paolo Mita, Song Cao, Mark Grivainis, Li Ding, John LaCava, Kathleen H. Burns, Jef D. Boeke, David Fenyo Tags: Systems Biology Biological Sciences Source Type: research