Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production [Microbiology]
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from S. aureus that bind directly to major histocompatibility complex (MHC) class II and T cell receptors to drive extensive T cell activation and cytokine release. Although...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Stephen W. Tuffs, Mariya I. Goncheva, Stacey X. Xu, Heather C. Craig, Katherine J. Kasper, Joshua Choi, Ronald S. Flannagan, Steven M. Kerfoot, David E. Heinrichs, John K. McCormick Tags: Microbiology Biological Sciences Source Type: research