Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion [Microbiology]

SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1) uses its C-terminal domain to block the messenger RNA (mRNA) entry channel of the 40S ribosome to inhibit host protein synthesis. However, how...

Source: Proceedings of the National Academy of Sciences - February 11, 2022 Category: Science Authors: Setu M. Vora, Pietro Fontana, Tianyang Mao, Valerie Leger, Ying Zhang, Tian-Min Fu, Judy Lieberman, Lee Gehrke, Ming Shi, Longfei Wang, Akiko Iwasaki, Hao Wu Tags: Microbiology, Coronavirus (COVID-19) Biological Sciences Source Type: research