TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation [Cell Biology]

Autophagy is a fundamental cellular process of protein degradation and recycling that regulates immune signaling pathways via multiple mechanisms. However, it remains unclear how autophagy epigenetically regulates the immune response. Here, we identified TRIM14 as an epigenetic regulator that reduces histone H3K9 trimethylation by inhibiting the autophagic degradation of the...

Source: Proceedings of the National Academy of Sciences - February 10, 2022 Category: Science Authors: Di Liu, Zhiyao Zhao, Yuanchu She, Lei Zhang, Xiangtian Chen, Ling Ma, Jun Cui Tags: Cell Biology Biological Sciences Source Type: research