Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly [Cell Biology]

Multiprotein assemblages are the intracellular workhorses of many physiological processes. Assembly of constituents into complexes can be driven by stochastic, domain-dependent, posttranslational events in which mature, folded proteins specifically interact. However, inaccessibility of interacting surfaces in mature proteins (e.g., due to “buried” domains) can obstruct complex formation. Mechanisms by which...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Cell Biology Biological Sciences Source Type: research