Poly-2-methyl-2-oxazoline-modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration [Medical Sciences]

Bioprosthetic heart valves (BHV) fabricated from glutaraldehyde-fixed heterograft tissue, such as bovine pericardium (BP), are widely used for treating heart valve disease, a group of disorders that affects millions. Structural valve degeneration (SVD) of BHV due to both calcification and the accumulation of advanced glycation end products (AGE) with associated...

http://www.pnas.org/content/119/6/e2120694119.short?rss=1

Source: Proceedings of the National Academy of Sciences - February 7, 2022 Category: Science Authors: Andrey Zakharchenko, Yingfei Xue, Samuel Keeney, Christopher A. Rock, Ivan S. Alferiev, Stanley J. Stachelek, Hajime Takano, Tina Thomas, Chandrasekaran Nagaswami, Abba M. Krieger, Michael Chorny, Giovanni Ferrari, Robert J. Levy Tags: Medical Sciences Biological Sciences Source Type: research