Differential interferon-{alpha} subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection [Immunology and Inflammation]

Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies, and have been successfully employed for the treatment of viral diseases. Humans express 12 IFN-alpha (α) subtypes, which activate downstream signaling cascades and result in distinct patterns of immune responses and differential antiviral...

Source: Proceedings of the National Academy of Sciences - February 7, 2022 Category: Science Authors: Jonas Schuhenn, Toni Luise Meister, Daniel Todt, Thilo Bracht, Karin Schork, Jean-Noel Billaud, Carina Elsner, Natalie Heinen, Zehra Karakoese, Sibylle Haid, Sriram Kumar, Linda Brunotte, Martin Eisenacher, Yunyun Di, Jocelyne Lew, Darryl Falzarano, Jieli Tags: Immunology and Inflammation, Coronavirus (COVID-19) Biological Sciences Source Type: research