Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology

Publication date: Available online 20 March 2015 Source:Saudi Pharmaceutical Journal Author(s): Zenab Attari , Amita Bhandari , P.C. Jagadish , Shaila Lewis The purpose of this study was to develop nanosuspension based on combinative technology to enhance the intestinal absorption of Olmesartanmedoxomil(OLM), a potent antihypertensive agent with limited oral bioavailability. Two combinative approaches were employed and then characterized. In vitro intestinal absorption of OLM nanosuspension and plain OLM was studied using non-everted rat intestinal sac model.Optimal OLM nanosuspension was prepared by a combination of ball milling and probe sonication using stabilizer, poloxamer 407. The formula exhibited particle size of 469.9 nm and zeta potential of -19.1 mV, which was subjected to ex vivo studies. The flux and apparent permeability coefficient in intestine from OLM nanosuspension were higher than the plain drug, thereby suggesting better drug delivery.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research