The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice [Neuroscience]
Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a ubiquitylation-like pathway that is critical in various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, the...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Huilin Yu, Haiyu Luo, Luping Chang, Shisheng Wang, Xue Geng, Lijing Kang, Yi Zhong, Yongliang Cao, Ranran Wang, Xing Yang, Yuanbo Zhu, Mei-Juan Shi, Yue Hu, Zhongwang Liu, Xuhui Yin, Yunwei Ran, Hao Yang, Wenying Fan, Bing-Qiao Zhao Tags: Neuroscience Biological Sciences Source Type: research